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Ketamine drug’s potential as a treatment for depression and antidote to suicidal thoughts has drawn researchers’ attention. They’ve studied and administered it in controlled, clinical settings to help with treatment-resistant depression and other conditions. To be clear: Casual use is not a treatment for depression. But doctors have developed a protocol for medically supervised use that may help people who don’t get relief from other medications. “We’re reaching out in a new way to patients who have not responded to other kinds of treatments and providing, for some of them, the first time that they’ve gotten better from their depression,” Krystal says.
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When used alone, only one in 16 people taking codeine phosphate at a dose of 60mg will receive effective pain relief. When combined with paracetamol (acetaminophen) however, one in two people obtain effective pain relief. There is a dose-response effect, so that the combination of codeine phosphate 60mg plus paracetamol (acetaminophen) 600mg is twice as effective as codeine phosphate 30mg plus paracetamol (acetaminophen) 300mg when used for post-operative pain relief. However, higher doses of codeine increase the chance of side effects. Codeine-based medicines have been found to reduce cough severity, but not cough frequency. The common side effects of codeine phosphate include drowsiness, dizziness, headache, nausea and vomiting.
Prescribing tramadol to minimise adverse effects. The usual dose of tramadol is 50–100 mg per dose, with a maximum daily dose of 400 mg, and at least four hours between doses.5 Older patients are most at risk of developing tramadol-related adverse effects, in which case the maximum daily dose should be reduced to 300 mg.5 In patients with hepatic or renal dysfunction, who may have reduced elimination of tramadol, a low starting dose of immediate-release tramadol, e.g. 50 mg, with titration to effect and 12-hour dosing is appropriate;3,4 modified-release tramadol should be avoided in these patients.5 Tramadol should be avoided in patients with severe renal dysfunction, i.e. a creatinine clearance < 10 mL/minute. If patients experience nausea with the use of tramadol, consider lowering the dose and concurrently using paracetamol (see below) or switch the patient to codeine, dihydrocodeine or a NSAID. Modified-release tramadol may be associated with fewer adverse effects in some patients.
Taking all this into consideration, how satisfied are parents with medications their children are taking for ADHD? Overall, only 41 percent were highly satsfied (16 percent were "completely satisfied" and 25 percent were "very satisfied"). About one-third (29 percent) were dissatisfied and the remainder were fairly satisfied (30 percent). There were no differences in overall satisfaction between those groups trying amphetamines or methylphenidates. Most amphetamines and methylphenidates are available in standard doses and extended- or sustained-release forms. Standard release means that the medication will be in your child's system for a given period of time (usually about three hours), at which point another dose needs to be administered to maintain the effect. Extended- or sustained-release medications are usually given in the morning and slowly release the effective component of the medication throughout the day.
Zaleplon ( Sonata ): Of all the newer sleeping pills, Sonata stays active in the body for the shortest amount of time. That means you can try to fall asleep on your own. Then, if you're still staring at the clock at 2 a.m., you can take it without feeling drowsy in the morning. But if you tend to wake during the night, this might not be the best choice for you.
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